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| Dose level (mg/m2) |
Plasma total (ng/ml) (No. Pts) |
Plasma lactone (ng/ml) |
% Plasma lactone | CSF total (ng/ml) |
CSF lactone (ng/ml) |
CSF/plasma ratio (%) |
|---|---|---|---|---|---|---|
| 0.25 | 1.02 (3) | 0.42 (1) | 34.3 | ND | ND | |
| 0.5 | 2.48 (3) | 1.07 (3) | 43.1 | 0.45 | ND | 17.8 |
| 0.75 | 2.74 (4) | 0.54 (4) | 23.2 | 0.76 | ND | 21.8 |
| 1.0 | 4.15 (5) | 1.36 (5) | 34.8 | 1.09 | 0.5 (1) ND (3) | 28.0 |
ND Not detectable
