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. Author manuscript; available in PMC: 2012 Jan 24.
Published in final edited form as: Nat Genet. 2011 Jun 28;43(7):616–617. doi: 10.1038/ng.870

Figure 1.

Figure 1

Model of pro-survival effects of PANDA lncRNA during the DNA damage response. Upon DNA damage, p53 activates expression of target genes such as CDKN1A which encodes the cell cycle regulator p21. p53 also activates expression of PANDA lncRNA encoded upstream of the CDKN1A..PANDA physically interacts with the NF-YA subunit of the NF-Y transcription factor and prevents it from cooperating with p53 on the promoters of p53-dependent pro-apoptotic targets, such as FAS.