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. 2012 Jan 24;7(1):e30283. doi: 10.1371/journal.pone.0030283

Figure 5. Two-step regulation time course dynamics varying the period of Inline graphic.

Figure 5

The plots show the expression of a gene Inline graphic (blue) controlled by the symmetric signal Inline graphic (black) for the two-step model. The left (right) column shows the case in which the value of Inline graphic (green dashed line) is above (below) the average value at stationary regime of the transcription factor Inline graphic (red curve). The first three rows show the time-course dynamics for Inline graphic, Inline graphic and Inline graphic for three different oscillation periods, whereas the last row shows the average value of Inline graphic at stationary regime as a function of the period of oscillation of Inline graphic. Inline graphic is turned off in the case Inline graphic as the period of oscillation decreases (left column) while it is increasingly expressed in the case Inline graphic (right column). The parameters used in the simulations are: Inline graphic, Inline graphic, Inline graphic, Inline graphic (this value has been chosen so that Inline graphic) and Inline graphic for the left column and Inline graphic for the right column.