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. 2012 Jan 24;7(1):e30452. doi: 10.1371/journal.pone.0030452

Figure 2. Inhibitory effect of SERA5 prodomain on parasite growth.

Figure 2

Panel A: Schizonts were accumulated in a dose-dependent manner upon treatment of culture with SERA5 PD (referred as PD) at ring stage. Control P. falciparum protein recombinant HMGB2 had no effect on parasite growth. E-64 (10 µM) was taken as positive control, which caused significant accumulation of schizonts. Geimsa-stained smears of parasite culture were observed by light microscopy after 48 hours of treatment. Data is representative of mean of triplicate experiments. Error bars represent standard deviation of mean. Panel B: Schizonts were accumulated in a dose-dependent manner upon treatment of culture with SERA5 PD (referred as PD) at late trophozoite stage. E-64 (10 µM) was taken as positive control, which caused significant accumulation of schizonts. Geimsa-stained smears of parasite culture were observed by light microscopy after 24 hours of treatment. Data is representative of mean of triplicate experiments. Error bars represent standard deviation of mean.