Table 3. Hazard ratios for HPV infection clearance probability for HIV-1-infected adolescent females from the REACH cohort, univariable and multivariable Cox proportional hazard regression (results are presented with 95% CIs).
Parameter | HPV16/16-like | HPV18/18-like | HPV56/56-like | HPV low risk | ||||
Univariable | Multivariable | Univariable | Multivariable | Univariable | Multivariable | Univariable | Multivariable | |
CD4/100 (per each 100cells/mm3 increase) | 1.08(1.06,1.10)‡ | 1.15(1.08,1.23)† | 1.05(1.03,1.08)† | 1.34(1.24,1.45)‡ | ns | ns | 1.11(1.08,1.14)‡ | 1.24(1.12,1.36)† |
CD4 level ≥200 cells/mm3 (vs. <200 cells/mm3) | 1.68(1.32,2.14)† | n/a | 1.80(1.40,2.31)† | n/a | ns | n/a | 2.53(1.81,3.53)† | n/a |
CD4 level ≥500 cells/mm3 (vs. <500 cells/mm3) | 1.65(1.42,1.91)‡ | n/a | 1.70(1.45,1.98)‡ | n/a | ns | n/a | 2.11(1.74,2.57)‡ | n/a |
HIV-1 VL | 0.82(0.76,0.88)† | ns | 0.79(0.73,0.86)‡ | ns | ns | ns | 0.74(0.67,0.81)† | ns |
HAART | ns | 1.42(1.22,1.66)† | ns | ns | ns | ns | ns | ns |
HAART with PI | 1.57(1.33,1.84)† | 1.77(1.50,2.08)‡ | 1.75(1.47,2.08)‡ | 1.79(1.50,2.13)‡ | ns | ns | 1.68(1.36,2.08)† | 1.82(1.47,2.27)† |
Any HPV infection at baseline | ns | ns | ns | ns | ns | ns | ns | ns |
Chlamydia trachomatis | ns | ns | ns | ns | ns | ns | 1.69(1.33,2.14)† | 1.60(1.26,2.02)† |
Note: †p<0.05; ‡p<0.001; ns - not significant; n/a – not applicable.