Table 4. CD4 T-lymphocyte counts (basic model M1), HIV VL (M6 model), and HAART with PI (M7 model) effects on probability of HPV clearance, by phylogenetic HPV group, in HIV-1-infected adolescent females, REACH cohort.
HPV type | Model | u00 (SE) | β00 (SE)a | u11 (SE) | β11 (SE)a | Additional parameter in the model (SE) |
16/16-like | M1 | −3.5±0.15** | −0.14±0.25 | −1.52±0.15** | 1.15±0.27** | –– |
M6 | −3.47±0.17** | −0.09±0.28 | −0.7±0.47* | 0.79±0.35** | −0.17±0.09* | |
M7 | −3.5±0.14** | −0.13±0.25 | −1.65±0.17** | 1.23±0.27** | 0.33±0.18* | |
18/18-like | M1 | −3.38±0.14** | −0.47±0.25* | −1.29±0.18** | 1.58±0.36** | –– |
M6 | −3.48±0.16** | −0.2±0.28 | −0.98±0.64* | 2.1±0.66** | −0.14±0.12 | |
M7 | −3.38±0.13** | −0.47±0.25** | −1.38±0.18** | 1.58±0.36** | 0.29±0.21* | |
56/56-like | M1 | −2.82±0.19** | −0.59±0.35* | −0.99±0.22** | 0.72±0.38* | –– |
M6 | −3.05±0.24** | −0.35±0.4 | −0.90±0.67* | 0.7±0.51 | −0.05±0.13 | |
M7 | −2.82±0.19** | −0.58±0.35* | −1.03±0.25** | 0.74±0.38** | 0.09±0.25 | |
Low risk | M1 | −3.69±0.15** | −0.26±0.27 | −1.31±0.21** | 1.5±0.41** | –– |
M6 | −3.82±0.17** | 0.05±0.29 | −0.13±0.64 | 0.93±0.51* | −0.26±0.13** | |
M7 | −3.69±0.15** | −0.27±0.27 | −1.42±0.22** | 1.54±0.41** | 0.33±0.24 |
Note:
*0.05≤p<0.1;
**p<0.05.u00, β00, u11, and β11 are related to the parameters in equation (2)
– the units of β00 and β11 are 1000/[C], where [C] are the units of CD4 cell counts, i.e., cells/mm3.
SEs were obtained by re-estimating the model in which probability at specific value of CD4 cell count was chosen as a model parameter instead of .