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. 2012 Jan 24;7(1):e30773. doi: 10.1371/journal.pone.0030773

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Chun et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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eSS-predicted levels of free 25OHD and 1,25(OH)₂D relative to total serum levels of these metabolites for in vitro tissue culture conditions (5% serum) and in vivo (100% serum) according to DBP genotype (GC allele combinations). X-axis indicates total serum concentrations of 25OHD (nM) or 1,25(OH)₂D (pM) and Y-axis indicates concentration of free 25OHD or 1,25(OH)₂D. Concentration of (A) 1,25(OH)₂D = 5 pM (5% serum), (B) 25OHD = 2.5 nM (5% serum), (C) 1,25(OH)₂D = 100 pM (100% serum) or (D) 25OHD = 50 nM (100% serum) were fixed.