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. 2012 Jan 24;7(1):e30638. doi: 10.1371/journal.pone.0030638

Figure 3. GFAP-Cre mediated conditional knockdown of BCCIP causes microcephaly.

Figure 3

(A) a representative set of brains from wild type (WT), GFAP-Cre, BCCIP-CON, and BCCIP-CKD mice at P21, illustrating the reduced cerebrum and cerebellum in the BCCIP-CKD mice. (B) the brain weight of wild type (WT), GFAP-Cre, BCCIP-CON and BCCIP-CKD mice at age P21. (C) brain weight of BCCIP-CON (white bar) and BCCIP-CKD (gray bar) mice at various ages, ranging from day 1 (1D) to approximately 18 months. Asterisks indicate the statistic significance between BCCIP-CON and BCCIP-CKD of the same age (*: P<0.05; **: P<0.01; ***: P<0.001). The “n” values indicate the number of mice measured at the time point. D: day; W: week; and M: month.