Table 2.
GAPDH normalized absolute MMP and TIMP concentrations (ng MMP or TIMP/ ng GAPDH) in normal and aneurysmal aorta from all BAV patients or BAV patients stratified by valve morphology (L-N, R-L, R-N). Values are expressed as the mean ± SEM
| MMP | Normal | BAV | L-N | R-L | R-N |
|---|---|---|---|---|---|
| MMP-1 (×10−5) | 1.16±0.30 | 1.03±0.19 | 1.20±0.71 | 1.09±0.24 | 0.75±0.29 |
| MMP-2 (×10−3) | 11.79±2.04 | 15.17±1.85 | 23.66±7.55 | 13.61±2.05 | 14.89±3.63 |
| MMP-3 (×10−5) | 15.52±3.66 | 13.96±1.80 | 25.50±7.30 | 12.38±1.95 | 11.72±3.10 |
| MMP-7 (×10−5) | 6.19±1.09 | 3.44±0.59 | 8.42±4.00 | 2.80±0.45 | 2.88±0.83 |
| MMP-8 (×10−3) | 8.96±3.13 | 5.15±1.01 | 3.32±1.56 | 6.06±1.38 | 3.24±1.54 |
| MMP-9 (×10−3) | 4.37±1.48 | 11.47±2.04 | 12.05±5.59 | 11.68±2.42 | 10.39±5.57 |
| MMP-12 (×10−5) | 1.00±0.38 | 1.31±0.29 | 1.95±0.71 | 1.30±0.40 | 0.86±0.35 |
| TIMP-1 (×10−3) | 25.10±4.35 | 15.82±1.68 | 23.33±8.22 | 14.57±1.70 | 14.69±2.51 |
| TIMP-2 (×10−3) | 31.63±4.82 | 34.45±3.53 | 45.99±14.46 | 32.91±4.18 | 31.41±4.42 |
| TIMP-3 (×10−3) | 6.11±0.90 | 5.68±0.63 | 5.56±1.43 | 5.68±0.87 | 5.75±0.92 |
| TIMP-4 (×10−5) | 9.06±1.43 | 3.47±0.27 | 4.30±1.25 | 3.19±0.29 | 3.81±0.41 |