Table 3.

MMP activity and MMP or TIMP protein abundance in normal and aneurysmal aorta from all BAV patients or BAV patients categorized by valve morphology (L-N, R-L, R-N). Values (mean ± SEM) are expressed as a percent of normal aorta

	Normal	BAV	L-N	R-L	R-N
Global MMP Activity	100±20	273±62 *	284±71 *	286±89 *	223±85
MMP-1	100±26	89±17	103±61	93±21	64±25
MMP-2	100±17	129±16	201±64	115±17	126±31
MMP-3	100±24	90±12	164±47	80±13	75±20
MMP-7	100±18	56±10 *	136±65	45±7 * #	46±13 *
MMP-8	100±35	58±11 *	37±17 *	68±15 *	36±17 *
MMP-9	100±35	263±47 *	276±128	267±55 *	238±128
MMP-12	100±37	130±29	194±71	130±39	85±35
TIMP-1	100±17	63±7 *	93±33	58±7 *	59±10 *
TIMP-2	100±15	109±11	145±46	104±13	99±14
TIMP-3	100±15	93±10	91±23	93±14	94±15
TIMP-4	100±16	38±3 *	48±14 *	35±3 *	42±5 *

^*p<0.05 versus reference normal set at 100%;

^#p<0.05 versus L-N group