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. Author manuscript; available in PMC: 2013 Jun 24.
Published in final edited form as: Mol Cell Endocrinol. 2011 Sep 16;357(1-2):43–49. doi: 10.1016/j.mce.2011.09.017

Figure 2. Integration of PR rapid signaling and transcriptional activities.

Figure 2

Progesterone (P4) binding to PR induces the rapid association of PR and c-Src. This interaction leads to a c-Src-dependent activation of the MAPK module through Ras/Raf signaling. This MAPK activation can lead to phosphorylation (P) of PR, transcriptional coactivators, and/or activation of downstream MAPK target genes (i.e. Cyclin D1). Phosphorylated PRs can activate transcription directly by binding to progesterone response elements (PREs) or indirectly though tethering interactions (i.e. SP1). Extranuclear and classical actions of PR are likely highly integrated actions, rather than separable events mediated by discrete populations of receptors.