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. Author manuscript; available in PMC: 2013 Jun 24.
Published in final edited form as: Mol Cell Endocrinol. 2011 Sep 16;357(1-2):43–49. doi: 10.1016/j.mce.2011.09.017

Figure 3. Ck2-dependent PR-B Ser81 phosphorylation mediates isoform-specfic target gene selection.

Figure 3

In response to progesterone binding or cell cycling (G1/S), PR-B is phosphorylated at Ser81 by ck2. Phospho-Ser81-PR-B/ck2 complexes are recruited to promoter/enhancer regions of Ser81-responsive PR-target genes. Phosphorylation at PR-B Ser81 (not present in PR-A) is a major determinant of PR isoform-specific target-gene selectivity.