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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Glia. 2011 Dec 5;60(3):476–486. doi: 10.1002/glia.22281

Fig. 5. Inhibition of mTOR attenuates efficient transition of immature OLs to mature OLs.

Fig. 5

Early progenitors were grown in the absence (Cont) or presence of rapamycin from 0 to 5 days and analyzed by double immunolabeling for O1, and CNP (A,B) or O1 and MBP (C,D). Quantification of the percentage of O1+ cells that co-express CNP (B) or MBP (D) shows that while there was no effect of mTOR inhibition on the transition of O1+ immature OLs to CNP+ immature OLs, their progression to MBP+ mature OLs was significantly inhibited. Error bars, SEM, N=4 independent cultures in duplicates. Scale bars, 50 um.