Figure 1.

Chimerism following transplantation of congenic BMCs pretreated in vitro with Diprotin A. Recipient mice were conditioned with 1 Gy TBI and received 15 × 10⁶ congenic CD45.2 BMCs (n = 9/control group A, n = 9/Diprotin A–treated group B). BMCs of group B were treated in vitro with 5 mM Diprotin A before transplantation. The levels of chimerism in blood over time (A), was determined by flow cytometry and is presented as means for Diprotin A–treated (squares) and untreated (dotted line with diamonds) groups. In (B) chimerism in BM and spleen at the end of follow-up is depicted in box and whisker plots. No significant differences were noted between both groups.