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DPPIV enzymatic activity in serum after in vivo inhibition with Diprotin A or sitagliptin. DPPIV enzymatic activity in serum was measured 2 (peak) and 12 hours (trough) after in vivo treatment with Diprotin A (group D) or sitagliptin (group E). DPPIV enzymatic activity at peak and trough exposure is depicted for Diprotin A– (A) and sitagliptin-treated [(B) congenic, (C) allogeneic model] groups (n = 3–4 randomly selected mice per group, congenic BMT).
