Fig. 4.

Spike-evoked adenosine release displays short-term plasticity. a Adenosine release evoked by a single spike in the parallel fibres of a cerebellar slice. Ai raw trace, inset shows the decay of the signal can be fitted by a single exponential process, green line is a minimal theoretical model of the data (rapid initial rise of adenosine followed by exponential decay, details in [20]); and Aii deconvolution of the signal (effectively to remove the slowest component of the decay due to diffusion), green line is deconvolution of the minimal theoretical model. b Demonstration of short-term plasticity of adenosine release during paired stimuli at different interpulse intervals. Bi raw records at intervals indicated below, inset showing that the decay can again be fitted by a single exponential process, Bii the deconvolved records. At intervals of 30 s or longer, adenosine release undergoes paired pulse depression. At very short intervals (50 ms), adenosine release exhibits paired pulse facilitation. Reproduced with permission from [20]