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Inhibitory activity of crizotinib and TAE684 on ALK-positive and ALK-negative NSCLC lines
| Crizotinib | TAE684 | ||||
|---|---|---|---|---|---|
| Cell line | ALK status | Cell growth (GI50, nm) | p-ALK (IC50, nm) | Cell growth (GI50, nm) | p-ALK (IC50, nm) |
| H3122 | EML4-ALK v1 | 62 ± 18 | 43 ± 37 | 1.5 ± 0.6 | 1.0 |
| H2228 | EML4-ALK v3a/3b | 121 ± 61 | 55 ± 4 | 3.8 ± 2 | 3.7 |
| H838 | ALK negative | 1307 ± 270 | ND | 406 ± 217 | ND |
| H23 | ALK negative | 1773 ± 743 | ND | 618 ± 283 | ND |
ND, not determined.
