Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The biased agonist cap-ET under the PAO-sensitized condition effectively introduced Ca2+-dependent receptor desensitization. (A) AEA and AM404 induced less Ca2+-dependent desensitization of TRPV1 compared to capsaicin (n = 4 for each treatment). (B) Sensitization of TRPV1 by 10 µM PAO sufficiently increased the efficacy of 10 µM cap-ET for induction of Ca2+-dependent channel desensitization (*p < 5 × 10−4, unpaired t-test, n = 4 for each treatment).
