Figure 2.

Modulation of TRPA1 activity and trafficking. (1) Activation of PKA and PLC by PAR-2 or B₂R induces trafficking of TRPA1 to the plasma membrane. (2) PKA and PKC-dependent phosphorylation potentiate TRPA1 activation. (3) Activation of PLC downstream of PAR-2 or B₂R enhances TRPA1 activity by releasing the channel from PIP₂-mediated inhibition. (4) DAG modulates TRPA1 activity either directly, by activation of the channel itself, or in a PKC-dependent manner. 4-hydroxynonenal, 4-HNE; B₂ Bradykine receptor, B₂R; Diacylglycerol, DAG; protease-activated receptor-2, PAR-2; protein kinase A, PKA; protein kinase C, PKC; phosphatidylinositide, PIP₂; phospholipase C, PLC.