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. 2011 Dec 1;287(3):1779–1789. doi: 10.1074/jbc.M111.267732

FIGURE 1.

FIGURE 1.

Suppression of IGFBP-4 following endothelial cell interactions with denatured collagen. The relative expression of IGFBP-4 was examined in HUVECS following binding to either native collagen type IV (N Coll-IV) or denatured collagen type IV (D Coll-IV). HUVEC were seeded on collagen-coated wells and allowed to incubate, and total cell lysates (A) or mRNA (B) were isolated. A, Western blot of IGFBP-4 expression in HUVECs following 4-h interactions with either native or denatured collagen type IV. B, quantitative RT-PCR analysis of the relative abundance of IGFBP-4 mRNA following 1-h interaction with either native or denatured collagen type IV.