Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A hypothetical model for recruitment of DNA methyltransferases by ZFP57 via KAP1. As shown in the diagram, the zinc finger domain of ZFP57 presumably binds to its target regions such as a differentially methylated region (DMR) in an imprinted domain. The KRAB box of ZFP57 can bind to KAP1, which in turn recruits DNA methyltransferases (DNMT). DNA methyltransferases then can either initiate or maintain DNA methylation at the DMR.
