Table 1.
Ank T4SS effectors with known functions
| Ank | Number of repeats | Other domains/motifs | Interacting host protein | Function | Pathogen host cell | References |
| Anaplasma | ||||||
| AnkA | 11 | EPIYA motif | SHP-1, Abi-1 | Binds eukaryotic DNA, influences CYBB expression | Neutrophil | 13–16 |
| Legionella | ||||||
| AnkB | 2 | F-box domain | Parvin B | Recruitment of ubiquitinated proteins to the Legionella-containing vacuole | 26, 28–30, 33, 34 | |
| AnkH AnkJ |
2 3 |
Unknown | Required for intracellular replication | Macrophage | 22 | |
| AnkX | 4 | FIC domain | Rab1 and Rab35 | Phosphocholine transferase that regulates Rab1 and Rab35 activity | 25 | |
| Coxiella | ||||||
| AnkG | 2 | p32 (gC1qR) | Inhibits apoptosis | Macrophage | 41 |