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. Author manuscript; available in PMC: 2012 Jan 25.
Published in final edited form as: N Engl J Med. 2009 Mar 29;360(17):1705–1717. doi: 10.1056/NEJMoa0900559

Figure 1. Enrollment and Outcomes in the STICH Hypothesis 1 and Hypothesis 2 Trials.

Figure 1

Eligible patients who had an ejection fraction of 35% or less and coronary artery disease that was amenable to coronary-artery bypass grafting (CABG) were stratified for randomization on the basis of protocol criteria regarding eligibility for medical therapy and for surgical ventricular reconstruction (SVR). Patients who were eligible for medical therapy with or without CABG but not for CABG with SVR were randomly assigned within stratum A. Data from these patients are being collected in the ongoing Hypothesis 1 component of the Surgical Treatment of Ischemic Heart Failure (STICH) trial. Patients who were eligible for medical therapy with or without CABG or for CABG with SVR were randomly assigned within stratum B. Patients who were not eligible for medical therapy alone but who were eligible for CABG or CABG with SVR were randomly assigned within stratum C. Patients in stratum B and stratum C who were then randomly assigned to undergo CABG with or without SVR are included in the 1000-patient cohort that was evaluated in the Hypothesis 2 trial.