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. 2012 Jan 23;196(2):261–276. doi: 10.1083/jcb.201108088

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© 2012 Haberman et al.

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Figure 1. — Loss of n-syb causes slow degeneration in adult photoreceptor neurons. (A–E) Phalloidin labeling of rhabdomere profiles from ommatidial cross sections of 5-wk-old adult Drosophila eyes provides a morphological index of photoreceptor degeneration. Compared with wild type (A), rhabdomeres are mostly lost in v100 (B), partially lost in n-syb (C), rescued in the n-syb mutant by photoreceptor-specific n-syb expression (D), and normal in syt (E). (F–J) ERG recordings provide a functional measure of photoreceptor integrity. ERG recordings are shown from 5-wk-old wild-type (F), v100 (G), n-syb (H), n-syb rescue (I), and syt (J) eyes. Note normal size of sustained negative photoreceptor response (arrow in F) in F, I, and J and reduced on transients (arrowhead in F) in G, H, and J, indicating loss of neurotransmission. (K) Counts of rhabdomeres/ommatidium for 1-wk-old flies raised in 12-h light/dark cycles (1LD), constant light (1LL), and 5 wk of light/dark cycles (5LD). (L) Magnitude of ERG depolarization normalized to wild-type photoreceptor response (arrow in F). Bar, 10 µm. All error bars are SEM for n > 50 for all experiments.