Figure 6.

CCL2 concentrations increase in both the ipsilateral and contralateral cortex following a controlled cortical impact. Within four hours of a brain injury, CCL2 increases (p < 0.05) in both the ipsilateral and contralateral cortex in comparison to control. In comparison to both control and contralateral tissue, the ipsilateral hemisphere continued to express elevated (p < 0.05) concentrations for seven days. In contrast, the contralateral cortex only demonstrated an elevated expression in comparison to control (p < 0.05) at 4, 12, and 24 hours, returning to normal levels by three days after injury. All values are mean ± SEM, n = 5. ^*At each time point noted, ipsilateral differs from control tissue, p < 0.05. ^±At each time point noted, contralateral differs from control tissue, p < 0.05. Differences between the ipsilateral and contralateral cortices are denoted by placing the appropriate p-value above the two bars.