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. 2007 Jun 6;27(23):6174–6184. doi: 10.1523/JNEUROSCI.0730-07.2007

Figure 2.

Figure 2.

PS1C410Y mutation carriers: PiB–PET and MRI images. Transaxial PiB–PET SUVRpons images from five cousins who carry the PS1C410Y mutation and a cousin without the mutation, CY-C(35). All are cognitively normal. The top row shows the MRI and PiB–PET scan of CY1(35) and the PiB–PET of the noncarrier cousin. The middle row shows the two other PS1C410Y carrier cousins studied in Pittsburgh. The bottom row shows two PS1C410Y carrier sibs (cousins of the Pittsburgh subjects) that were imaged at MGH (averaged over 20–60 min to facilitate comparison with the Pittsburgh images; see Materials and Methods). A tracing of the location of the striatum from each Pittsburgh subject's MRI scan is superimposed on the respective PiB image, but only the MRI for the CY1(35) subject is shown (top left).