Figure 3.

Sequence identity comparisons for the DBD-CC domain of the three DNA ligases from 4 diverse eukaryotes. Lig3 proteins are predicted based on conservation of the DBD-CC. The overall domain structure of the DNA ligases is shown on top. PIP, PCNA-interacting peptide; NLS, nuclear localization signal; DBD, DNA binding domain; CC, catalytic core; MLS, mitochondrial leader sequence; ZnF, zinc finger domain; BRCT, related to the C-terminal domain of BRCA1. Lig3a differs from Lig3β in containing a BRCT domain at the C terminus.