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. 2012 Feb;22(2):220–231. doi: 10.1101/gr.123497.111

Figure 5.

Figure 5.

Chromosomal abnormalities in plasma preceding relapse. CNVs based on 50 consecutive markers (SNP and/or CN) and a minimum segment size of 50,000 bp. Example of array karyotypes of cfDNA for one patient preceding relapse: (A) normal leukocyte DNA sample, (B) P1 cfDNA sample taken 6 yr after diagnosis, and (C) P2 cfDNA taken 1 mo before the patient was diagnosed with metastatic disease. There was a significant increase in CNVs detected between P1 and P2: P1, 387 (79.08%) amplifications and 96 (20.92%) deletions; P2, 1332 (53.67%) amplifications and 1150 (46.33%) deletions.

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