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Mutual exclusiveness of chromatin modifications and mCG by ChIP-methylC-seq. ChIP was performed for H3K9me3, H3K27me3, or H3K36me3 in HCC1954, followed by bisulfite conversion and sequencing. For 10-kb windows, mCG bias was compared to genomic background from methylC-seq (P ≤ 0.01, Fisher's exact test). Shown is the number of 10-kb windows showing significant differences, split by whether there is more or less mCG in the ChIP-methylC-seq sample.
