Table 2.
Association Between Selected Genotypes and Cervical and/or Endometrial Chlamydia trachomatis Infection Among Women With Pelvic Inflammatory Disease
| SNPs and Genotypes | Chlamydia Negative (N = 111), No. (%) | Chlamydia Positive (N = 94), No. (%) | AORa (95% CI) | P valueb |
| TLR 1 | ||||
| rs5743618 | ||||
| GG + GT | 37 (34.9) | 12 (16.0) | Referent | … |
| TT | 69 (65.1) | 63 (84.0) | 2.8 (1.3–6.2) | .008 |
| rs4833095 | ||||
| AA + AG | 46 (62.1) | 63 (56.3) | Referent | … |
| GG | 28 (37.8) | 49 (43.8) | 1.2 (.6–2.3) | .53 |
| TLR 4 | ||||
| rs1927911 | ||||
| TT | 47 (42.7) | 30 (33.7) | Referent | … |
| CT | 47 (42.7) | 27 (30.3) | 1.0 (.5–2.0) | .97 |
| CC | 16 (14.6) | 32 (36.0) | 3.7 (1.6–8.8) | .002 |
Logistic regression was used to derive odds ratios, 95% CIs, and P values.
Abbreviations: AOR, adjusted odds ratio; CI, confidence interval; SNP, single nucleotide polymorphisms; TLR, Toll-like receptor.
a
Adjusted for age.
b
Significant based on a permutated P value <.004.