Table 3.
Associations Between Selected Single-Nucleotide Polymorphisms (SNPs) and Upper Genital Tract Infection (UGTI)
| SNPs and Genotypes | UGTI Negativea (N = 101), No. (%) | UGTI Positivea (N = 64), No. (%) | AORb (95% CI) | P value |
| TLR 1 | ||||
| rs5743618 | ||||
| GG + GT | 29 (30.9) | 6 (12.2) | Referent | … |
| TT | 65 (69.2) | 43 (87.8) | 3.1 (1.2–8.1) | .0214 |
| rs4833095 | ||||
| AA + AG | 41 (44.1) | 17 (31.5) | Referent | … |
| GG | 52 (55.9) | 37 (68.5) | 1.7 (.8–3.5) | .1377 |
| TLR 4 | ||||
| rs1927911 | ||||
| TT | 43 (43.4) | 18 (30.0) | Referent | … |
| CT | 40 (40.4) | 19 (31.7) | 1.2 (.5–2.6) | .6889 |
| CC | 16 (16.2) | 23 (38.3) | 3.5 (1.6–8.8) | .0021 |
Logistic regression was used to derive odds ratios, 95% CIs, and P values.
Abbreviations: AOR, adjusted odds ratio; CI, confidence interval.
a
Upper genital tract infection defined as a positive PCR for C. trachomatis or a positive culture for Neisseria gonorrhoeae.
b
Adjusted for age.