Table 4.
Associations Between Selected Single-Nucleotide Polymorphisms (SNPs) and Pregnancy Among a Subset of Women With Chlamydia trachomatis Infection
| SNPs and Genotypes | Pregnant (N = 62), No. (%) | Not Pregnant (N = 32), No. (%) | AORa (95% CI) |
| TLR 1 | |||
| rs5743618 | |||
| GG + GT | 10 (21.2) | 2 (7.1) | NAb |
| TT | 37 (78.7) | 26 (92.9) | … |
| rs4833095 | |||
| AA + AG | 19 (41.3) | 9 (29.0) | Referent |
| GG | 27 (58.7) | 22 (71.0) | 0.5 (.3–.9) |
| TLR 4 | |||
| rs1927911 | |||
| TT | 18 (31.6) | 12 (37.5) | Referent |
| CT | 17 (29.8) | 10 (31.3) | 1.2 (.4–3.9) |
| CC | 22 (38.6) | 10 (31.3) | 1.0 (.6–2.1) |
Logistic regression was used to derive odds ratios and 95% CIs.
Abbreviation: AOR, adjusted odds ratio; CI, confidence interval; NA, not applicable.
a
Adjusted for age and history of infertility.
b
Cell count too small for analysis.