Figure 2.

Combination treatment of ITX 5061 with VX-950 (HCV NS3 protease inhibitor). Huh7 cells were infected with HCV2aChluc. A, Combination index (CI) of ITX 5061 in combination with VX950. Numerical values above the bars are the mean CI. Error bars represent the standard error of the mean of the CI. The 50% effective dose (ED₅₀), 75% effective dose (ED₇₅), and 90% effective dose (ED₉₀) refer to the combination index at the 50% effective concentration (EC₅₀), 75% effective concentration (EC₇₅), and 90% effective concentration (EC₉₀), respectively. B, With various concentrations of VX-950 (indicated on the x-axis) with (square) or without ITX 5061 (triangle). C, With various concentrations of ITX 5061 (indicated on the x-axis) with (square) or without VX-950 (triangle). Viral replication was measured by luciferase assay 72 hours after infection.