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HCV2aChLuc (A156S) protease mutant is resistant to VX-950 but not to ITX 5061. HCV2aChLuc (A156S) mutant virus (square) was inoculated onto Huh7 cells in the presence of either ITX 5061(A) or VX-950 (B) and incubated for 3 days. At 3 days after infection, the cells were lysed and measured by luciferase assay. The same assay was done with the wild type of HCV2aChLuc (circle) in parallel.
