Figure 4).

Autophagy in pancreatitis. Autophagy is induced during pancreatitis, but the degradation of autolysosomes is impaired with accumulation of large vacuoles. Reduced activity of the lysosomal cathepsins (Cat) L and B was detected in autophagosomes, with Cat L more greatly affected than Cat B. The imbalance between the lysosomal hydrolases Cat B and Cat L increases the intra-acinar trypsin leading to cell necrosis and inflammation