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Application of the allele affinity model of snpRNA-mediated regulation of microRNA expression and activity (Figs. 5 and S8) to development of the allele equilibrium hypothesis explaining a dynamic transition, the allele-specific phenotype-altering effects of trans-regulatory snpRNAs as the consequence of direct actions on microRNAs expression levels and activity and downstream effects of snpRNA-regulated microRNAs on mRNA abundance levels of protein-coding genes. See text for details.
