Table 3.

Multivariable Cox regression analysis identified an elevated CAV1 staining value in the tumor cytoplasm as an independent predictor of tumor specific survival.

	CAV1 expression in the tumor cell cytoplasm		CAV1 expression in the tumor cell membrane
Variable	HR (95% CI)	p-value	HR (95% CI)	p-value
Age	1.01 (0.99-1.01)	0.35	1.01 (0.98-1.03)	0.71
Sex		0.45		0.44
female	1 (Reference)		1 (Reference)
male	1.26 (0.70-2.28)		1.27 (0.69-2.23)
T-Stage		0.43		0.19
pT1	1 (Reference)		1 (Reference)
pT2	1.43 (0.19-10.86)	0.73	1.43 (0.19-10.92)	0.73
pT3	2.28 (0.30-17.58)	0.43	2.64 (0.35-20.28)	0.35
pT4	2.97 (0.27-33.25)	0.38	3.39 (0.30-37.89)	0.32
Metastatic disease		< 0.001		< 0.001
N/M0	1 (Reference)		1 (Reference)
N/M+	5.04 (2.66-9.54)		4.88 (2.60-9.16)
Differentiation		< 0.001		< 0.001
G1	1 (Reference)		1 (Reference)
G2	2.75 (1.07-7.10)	0.04	2.55 (0.99-6.55)	0.05
G3/4	12.02 (3.54-40.85)	< 0.001	12.29 (3.60-41.98)	< 0.001
CAV1 expression level		0.03		0.34
≤ median	1 (Reference)		1 (Reference)
> median	1.95 (1.08-3.51)		1.31 (0.75-2.30)