Table 2. Comparison of immune subsets in peripheral blood and pleural fluid of TB and non-TB patients.
| TB (n = 30) | non-TB (n = 11) | TB PF vs PB | PF TB vs no TB | |||
| Subset (%) | PB | PF | PB | PF | p-value | p-value |
| CD3 | 44[33–51] | 72[43–80] | 36[7.3–52] | 64[1.2–82] | 0.0045 | 0.7168 |
| CD4 | 26[21–33] | 45[33–61] | 22[15–27] | 34[2.7–63] | 0.0001 | 0.2147 |
| CD8 | 16[11–24] | 17[12–23] | 8.4[4.8–17] | 10[0.9–16] | 0.8092 | 0.0099 |
| 4/8 ratio | 1.5[0.9–2.1] | 3.4[1.5–5.0] | 2.7[1.6–4.8] | 2.4[1.4–5.6] | 0.0001 | 0.7145 |
| CD19 | 8.2[2.5–12.4] | 3.9[1.1–10] | 4.6[1.2–13] | 6.0[2.3–7.3] | 0.0691 | 0.8057 |
| CD56 | 8.6[4.6–13] | 2.5[1.6–4.6] | 5.3[3.5–10] | 1.0[0.1–4.7] | 0.0001 | 0.0813 |
| γδTCR | 3.0[0.8–3.7] | 1.5[1.0–2.8] | 1.8[1.2–6.6] | 2.1[0.4–3.0] | 0.5230 | 0.8176 |
| CD14 | 7.9[4.5–12] | 2.2[0.8–7.3] | 7.2[2.6–14] | 3.3[0.5–15] | 0.2673 | 0.6323 |
| CD11b+CD11c+ | 2.5[0.8–7.5] | 1.6[0.5–6.1] | 4.0[1.0–8.6] | 0.5[0.1–5.3] | 0.7937 | 0.3690 |
| CD4+CD25+ | 1.4[0.8–2.4] | 2.8[1.8–4.2] | 0.9[0.3–1.9] | 0.7[0.1–3.6] | 0.0016 | 0.0579 |
| Tregs | 1.0[0.4–1.5] | 2.3[1.4–3.1] | 0.6[0.2–1.0] | 0.5[0.0–2.3] | 0.0002 | 0.0291 |
| Tregs/Teff | 4.6[2.6–6.8] | 4.9[2.9–8.0] | 2.9[1.3–5.4] | 3.5[0.4–7.6] | 0.5774 | 0.3571 |
| CD4 N | 36[25–53] | 21[12–37] | 55[29–63] | 19[4.8–52] | 0.0004 | 0.8486 |
| CD4 CM | 27[15–42] | 49[30–63] | 25[14–31] | 24[0.3–34] | 0.0166 | 0.0048 |
| CD4 EM | 15[6.1–24] | 13[4.5–20] | 9.0[5.6–25] | 8.0[0.3–22] | 0.6158 | 0.2327 |
| CD4 TE | 7.8[5.3–11] | 3.9[2.3–5.4] | 8.1[6.4–21] | 11[1.6–29] | 0.1485 | 0.4839 |
| CD8 N | 34[21–54] | 52[22–74] | 31[13–56] | 55[8.1–66] | 0.0173 | 0.2722 |
| CD8 CM | 5.9[4.5–17] | 14[2.8–27] | 6.1[5.1–9.2] | 7.8[1.0–31] | 0.5531 | 0.4354 |
| CD8 EM | 7.0[2.9–14] | 3.0[1.5–14] | 4.8[1.2–17] | 2.4[0.1–13] | 0.0534 | 0.3395 |
| CD8 TE | 38[34–56] | 12[6.4–26] | 47[23–54] | 14[4.4–35] | 0.0005 | 0.8486 |
| CD4+CD127+ | 61[39–83] | 73[53–84] | 73[41–93] | 68[38–85] | 0.0175 | 0.2713 |
| CD8+CD127+ | 46[36–57] | 67[56–83] | 47[24–75] | 60[29–76] | 0.0005 | 0.1126 |
| CD4+CD38+ | 2.2[1.4–9.4] | 6.3[4.0–15] | 1.3[1.1–7.4] | 2.4[0.8–4.5] | 0.0143 | 0.0065 |
| CD56+CD38+ | 34[10–50] | 17[7.2–50] | 28[9.1–43] | 4.1[2.8–9.0] | 0.2634 | 0.0031 |
Values expressed as median[Interquartile range] of 30 subjects with pleural TB and 11 with pleural effusions caused by other diseases (non-TB); PB = peripheral blood; PF = pleural fluid; Tregs = regulatory T cells (CD4+CD25+CD127lo); Teff = effector T cells (CD4+); N = naïve; CM = central memory; EM = effector memory; TE = terminal effector.