Table 1. Effect of SEGRAs on HaCaT cell restitution.
| Dex | wound closure | CpdA | wound closure | ZK216348 | wound closure |
| [µM] | [%] | [µM] | [%] | [µM] | [%] |
| - | 65.89±2.64 | - | 66.0±2.38 | - | 63.82±2.31 |
| 0.01 | 61.63±3.03 | 0.1 | 67.06±4.15 | 0.1 | 58. 93±4.00 |
| 0.05 | 52.25±2.74 * | 1 | 64.41±2.17 | 1 | 59.93±3.16 |
| 0.1 | 46.26±5.08 ** | 5 | 65.13±2.97 | 5 | 60.92±4.58 |
| 0.5 | 38.10±2.79 *** | 10 | 61.21±3.48 | 10 | 62.14±4.34 |
| 1 | 27.80±1.64 *** | 20 | 64.94±2.36 | 20 | 57.36±5.07 |
HaCaT cells were wounded and cultured in the presence of Dex, CpdA or ZK216348 for 24 h. Cell migration was assessed using an in vitro migration assay. Data indicate mean values of remaining wounded area ± S.E.M., n = 3,
*P≤0.05,
**P≤0.01,
***P≤0.001 relative to control.