Table 4. Impacts of the different pathways evaluated by Gene Set Enrichment Analysis (GSEA) derived from Protein Analysis THrough Evolutionary Relationship (PANTHER).

GS	Size	Pathway	NES	NOM p-value	FDR
P00005	31	Angiogenesis	−1.17	0.28	0
P00027	17	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway	−1.16	0.28	0
P00004	42	Alzheimer disease-presenilin pathway	−1.12	0.33	0.35
P00047	37	PDGF signaling pathway	−1.12	0.32	0.26
P00029	37	Huntington disease	−1.08	0.41	0.35
P00059	21	p53 pathway	−1.06	0.43	0.31
P00006	28	Apoptosis signaling pathway	−1.06	0.50	0.28
P00048	18	PI3 kinase pathway	−1.04	0.46	0.27
P00031	45	Inflammation mediated by chemokine and cytokine signaling pathway	−1.03	0.49	0.26
P00019	19	Endothelin signaling pathway	−1.00	0.50	0.33
P00036	35	Interleukin signaling pathway	−0.98	0.51	0.37
P00057	62	Wnt signaling pathway	−0.98	0.54	0.34
P00052	44	TGF-beta signaling pathway	−0.89	0.66	0.56
P00034	43	Integrin signalling pathway	−0.89	0.68	0.53
P00012	40	Cadherin signaling pathway	−0.87	0.66	0.55
P00046	22	Oxidative stress response	−0.86	0.67	0.55
P00026	33	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway	−0.85	0.68	0.57
P04398	28	p53 pathway feedback loops 2	−0.83	0.74	0.58
P00016	23	Cytoskeletal regulation by Rho GTPase	−0.81	0.71	0.59
P00060	44	Ubiquitin proteasome pathway	−0.73	0.81	0.81
P00007	16	Axon guidance mediated by semaphorins	−0.67	0.87	0.90

GS, gene set; Size, numbers of miRs included; NES, nominal enrichment score; NOM p-value, nominal p-value; FDR, false discovery rate.