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. 2012 Jan 25;7(1):e30972. doi: 10.1371/journal.pone.0030972

Table 3. Hazard ratios (HR) and 95% confidence intervals for daytime sleep and chronic diseases stratified by prevalent hypertension.

Non-hypertensive participants Hypertensive participants
Daytime sleep No Yes No Yes
11 517 (90.4%) 1 223 (9.6%) 9 387 (86.3%) 1 493 (13.7%)
Overall chronic disease (cases/person-years)a 604/91 920 85/9 618 1 080/71 959 273/10 890
Crude rate per 1000 person-years 6.6 8.8 15.0 25.1
HR model 1b 1.0 0.82 (0.65–1.05) 1.0 1.22 (1.06–1.41)
HR model 2c 1.0 0.77 (0.61–0.98) 1.0 1.21 (1.04–1.39)
HR model 3d 1.0 0.75 (0.59–0.96) 1.0 1.13 (0.98–1.31)
Type 2 diabetes (cases/person-years) 178/91 920 24/9 618 521/71 959 118/10 890
Crude rate per 1000 person-years 1.9 2.5 7.2 10.8
HR model 1b 1.0 0.85 (0.54–1.33) 1.0 1.22 (0.99–1.51)
HR model 2c 1.0 0.81 (0.51–1.27) 1.0 1.21 (0.97–1.50)
HR model 3d 1.0 0.77 (0.49–1.22) 1.0 1.05 (0.84–1.30)
Myocardial infarction (cases/person-years) 51/91 920 10/9 618 105/71 959 31/10 890
Crude rate per 1000 person-years 0.6 1.0 1.5 2.8
HR model 1b 1.0 1.20 (0.58–2.49) 1.0 1.41 (0.92–2.17)
HR model 2c 1.0 1.00 (0.47–2.12) 1.0 1.31 (0.84–2.04)
HR model 3d 1.0 0.98 (0.46–2.09) 1.0 1.27 (0.82–1.98)
Stroke (cases/person-years) 36/91 920 9/9 618 95/71 959 29/10 890
Crude rate per 1000 person-years 0.4 0.9 1.3 2.7
HR model 1b 1.0 1.27 (0.58–2.76) 1.0 1.60 (1.03–2.49)
HR model 2c 1.0 1.12 (0.51–2.46) 1.0 1.54 (0.98–2.43)
HR model 3d 1.0 1.10 (0.50–2.42) 1.0 1.51 (0.96–2.37)
Cancer (cases/person-years) 341/91 920 43/9 618 366/71 959 96/10 890
Crude rate per 1000 person-years 3.7 4.5 5.1 8.8
HR model 1b 1.0 0.72 (0.52–1.00) 1.0 1.09 (0.86–1.38)
HR model 2c 1.0 0.68 (0.49–0.95) 1.0 1.08 (0.85–1.38)
HR model 3e 1.0 0.68 (0.49–0.95) 1.0 1.07 (0.84–1.37)
a

Type 2 diabetes, myocardial infarction, stroke or cancer, whichever occurs first.

b

Stratified by age and adjusted for sex.

c

Additionally adjusted for sleeping disorders (yes/no), sleep duration at night (<6, 6-<7, 7-<8, 8-<9, ≥9 h), alcohol intake from beverages (non-consumers, men: >0–12 g/d, >12–24 g/d, >24 g/d; women: >0–6 g/d, >6–12 g/d, >12 g/d), smoking status (never, former, current), walking, cycling, sports (hours/week), employment status (employed vs. unemployed), and education (technical school or lower degree vs. university of applied sciences or university degree).

d

Adjusted for the variables in model 2 plus BMI (kg/m2), waist-to-hip ratio, and history of high blood lipid levels at baseline (yes/no).

e

Model 3 for cancer includes the same covariates as models for type 2 diabetes, myocardial infarction and stroke, except history of high blood lipid levels at baseline (yes/no).