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. 1983 Dec 20;11(24):8861–8876. doi: 10.1093/nar/11.24.8861

Interaction of diamidino-2-phenylindole (DAPI) with natural and synthetic nucleic acids.

G Manzini, M L Barcellona, M Avitabile, F Quadrifoglio
PMCID: PMC326630  PMID: 6672773

Abstract

The interaction of DAPI with natural and synthetic polydeoxynucleotides of different base content and sequences was studied with circular dichroism, ultracentrifugation, viscosity and calorimetry. All the polymers show two types of binding. The strength of the interaction and its resistance to ionic strength are related to the content of AT clusters in the chain. On the other hand, sedimentation measurements rule out an intercalation mechanism. A model of DAPI interaction with DNA, similar to that displayed by distamycin and netropsin, is proposed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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