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. 2012 Jan 25;7(1):e30725. doi: 10.1371/journal.pone.0030725

Figure 6. p-ERK1/2 expression of in IBC tissues.

Figure 6

(A) The expression of p-ERK1/2 was tested in tumor tissue samples from patients with IBC using the rabbit anti-p-ERK1/2 antibody. (B) Proposed working model for the stimulation of estrogen receptor ligand-induced non-genomic signaling pathway via p-ERK1/2 activation in IBC cells. Estrogen receptor ligand rapidly activates p-ERK1/2 phosphorylation, leading to the activation of estrogen non-genomic signaling including cell migration and invasiveness in inflammatory breast cancer.