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PPF does not decrease CNS-1 tumor cell growth on the flank of rats, external to CNS microenvironment. Rats were first engrafted in the flank with CNS-1 cells, then treated daily with either 50 mg/kg PPF or saline intraperitoneally beginning the day of tumor engraftment. Tumors were measured daily, with no statistically significant difference in tumor growth observed. Data are representative of 2 experiments, 5 rats/group.
