Table 3.

Top candidates for the Arlm1 gene based on B6vs129 polymorphisms, differential expression in B6 and 129 male brains, hazard ratios for correlation to changes in GBM survival time in REMBRANDT (REMB) and TCGA datasets for males and females, and percentage of samples with copy number changes in human astrocytoma and GBM. Genes are listed in order of location in human genome

Genes on Mouse Chr 12 105–121Mb polymorphic between B6 and 129	Mouse B6 vs 129 Cn SNPs	Mouse B6 vs 129 UTR/Intron 1 SNPs	Mouse Brain Exp Fold Ratio 129S1/B6	Human Homolog	Human Location	Hazard Ratio Males REMB n = 153	Hazard Ratio Females REMB n = 95	Hazard Ratio Males TCGA n = 131	Hazard Ratio Females TCGA n = 79	Percent Amp in REMB Astro	Percent Del in REMB Astro	Percent Amp in REMB GBM	Percent Del in REMB GBM	Percent Amp in TCGA GBM	Percent Del in TCGA GBM
Itgb8	1	7	NP	ITGB8	7p21.1	NS	1.95c	2.02a	NS	3	0	15	0	70	3
Dnahc11	4	10	1.5	DNAH11	7p21	1.65b	1.44e	NS	NS	21	0	49	0	72	2
Cdca7l	1	48	NP	CDCA7L	7p15	1.76b	NS	1.67f	NS	19	0	45	0	72	2
Ncapg2	3	21	NC	NCAPG2	7q36.3	1.48b	NS	NS	3.74a,g	17	0	34	0	74	2
Wdr60	1	12	NC	WDR60	7q36.3	2.31d	NS	NS	NS	17	0	23	0	73	3
Vipr2	1	2	NC	VIPR2	7q36.3	0.66a	0.60b	0.70e	NS	16	5	23	0	74	2
Serpina1a	0	9	4.4	SERPINA1	14q32.13	1.57c	1.96b	NS	2.19e	0	5	0	0	4	27
Serpina3n	0	9	4.1	SERPINA3	14q32.13	1.82c	1.26e	NS	NS	0	5	0	0	4	26
Dicer1	1	2	0.7	DICER1	14q32.13	0.47b	NS	NS	0.46e	0	7	0	9	3	27
Tcl1	0	1	1.5	TCL1A	14q32.1	NS	0.65a	3.91b,g	NS	0	0	0	0	4	27
Bcl11b	0	1	NC	BCL11b	14q32.2	0.73a	0.47b	0.098d,g	NS	0	0	0	3	4	27
Evl	0	2	NC	EVL	14q32	0.60b	0.51c	0.12c,g	NS	0	5	0	3	4	26
Wdr25	0	0	NC	WDR25	14q32.2	0.39c	NS	10.50b,g	NS	7	5	0	8	4	26
Ppp2r5c	0	0	0.6	PPP2R5c	14q32.31	0.50c	0.59b	NS	NS	0	8	0	0	5	26
Wdr20a	0	3	NC	WDR20	14q32.31	0.43a,g	NS	NS	NS	0	8	0	0	5	26
Cdc42bpb	0	1	0.5	CDC42BPB	14q32.3	0.61a	0.65a	NS	0.43e,g	0	14	0	21	6	26
Xrcc3	0	3	NC	XRCC3	14q32.3	1.66a	NS	NS	NS	0	17	0	22	6	26
Tdrd9	0	1	1.5	TDRD9	14q32.33	0.76b	NS	NS	NS	0	8	0	5	5	26
Cdca4	0	0	2.1	CDCA4	14q32.33	1.70c	NS	NS	NS	0	7	5	3	5	25
Jag2	0	0	0.4	JAG2	14q32	4.97a	NS	0.027d,g	NS	0	7	5	3	5	26
Crip2	1	0	0.6	CRIP2	14q32.3	2.41a	NS	4.01b,g	NS	0	7	5	3	5	25
Crip1	0	8	NC	CRIP1	14q32.33	1.63b	NS	NS	NS	0	7	5	3	5	25

Abbreviations: NP, no probe; NC, no change; NS, not significant.

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

^dP < 0.0001.

^eP < 0.1.

^fUnderexp vs Intermed (2-fold change) is not significant (P = .18); Overexp vs Underexp (4-fold change) is significant (HR = 2.66, P = .020).

^gn < 5 for one group in comparison.