Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Jan 17;61(2):474–484. doi: 10.2337/db11-0141

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

PMC Copyright notice

FIG. 6. — Enhanced Bmf expression in RPTs from human kidneys from patients with diabetes. A: Bmf immunohistochemical staining in human kidney sections (original magnification ×200) from three nondiabetic cancer patients (a, patient with papillary variant carcinoma; b, patient with clear cell carcinoma; and c, patient with thyroid-like renal carcinoma) and three diabetic cancer patients (d, patient with papillary variant carcinoma and evidence of DN [nodular with tubular atrophy and interstitial fibrosis]; e, patient with clear cell carcinoma and no evidence of DN; and f, patient with clear cell carcinoma and nephroangiosclerosis with evidence of DN [secondary focal glomerulosclerosis, tubular atrophy, and interstitial fibrosis]). DT, distal tubule; G, glomerulus. B: Colocalization of Bmf expression and TUNEL-positive cells in human kidneys. Nondiabetic human kidney (patient I.D. #C,) and diabetic human kidney with DN (patient I.D. #D) were sectioned, subjected to TUNEL assay to visualize apoptotic cells (green), and then incubated with anti-Bmf antibody, followed by anti-goat AlexaFluor 594 to demonstrate Bmf expression (red). Cells staining positively for TUNEL and Bmf appear yellow (merged image). Original magnification ×200. Arrows indicate cells that stained positively for TUNEL and Bmf. G, glomerulus; DT, distal tubule. (A high-quality color representation of this figure is available in the online issue.)