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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Hypertension. 2011 Dec 27;59(2):241–247. doi: 10.1161/HYPERTENSIONAHA.111.179481

Table 2.

Additional explained variance by a random genetic risk score versus original genetic risk score

Additional explained variance
Phenotype Random genetic risk score (%) Original genetic risk score (%) P-value for difference
Adult systolic blood pressure (Rotterdam Study III) 1.0 † 1.2 † 0.07
Adult diastolic blood pressure (Rotterdam Study III) 1.3 † 1.7 † 0.01
Child systolic blood pressure (Generation R) 0.7 * 0.8 * 0.49
Child diastolic blood pressure (Generation R) 1.4 † 1.6 † 0.10
Hypertension – SBP scores (Rotterdam Study III) 1.1 † 1.4 † 0.02
Hypertension – DBP scores (Rotterdam Study III) 1.7 † 2.1 † 0.01
*

P value < 0.05

†

P value < 0.001

Random Genetic risk score – Genetic risk score calculated on SNP set containing ~565k SNPs which were randomly selected out of the discovery meta-analysis, irrespective of their P-value for association.

Original genetic risk score – Genetic risk score calculated on a SNP set with a Pdiscovery threshold of 0.3. This SNP set contains ~565k SNPs and showed the largest increase in explained variance.

The P-value for difference between the models was obtained by calculating the difference in Akaike Information Criterion between the random model and the original model. This difference follows a χ2 distribution with 1 degree of freedom