Table 4.

Rates and adjusted odds ratios of less severe cardiovascular events and cardiovascular symptoms for privately insured youth diagnosed with attention-deficit/hyperactivity disorder by current, former, and non-use of stimulants, by stimulant class

Stimulant Use Group	Day Level Event Rate per Million Days (n)	Odds Ratio (95% CI)	Adjusted Odds Ratio (95% CI)a
Less Severe Cardiovascular Events
Current methylphenidate use	1.06 (n=14)	1.57 (0.62–3.96)	2.14 (0.82–5.63)
Current amphetamine use	0.72 (n=7)	1.00	1.00
Past methylphenidate use	1.70 (n=45)	1.06 (0.59–1.91)	1.23 (0.67–2.25)
Past amphetamine use	1.84 (n=37)	1.00	1.00
Cardiovascular Symptoms
Current methylphenidate use	2.58 (n=34)	0.69 (0.43–1.10)	1.08 (0.66–1.79)
Current amphetamine use	3.72 (n=36)	1.00	1.00
Past methylphenidate use	2.57 (n=68)	0.98 (0.62–1.54)	1.13 (0.72–1.79)
Past amphetamine use	2.59 (n=52)	1.00	1.00

Note: See text for definition of stimulant use groups. Less severe event analyses also adjusted for cardiovascular symptoms. Less severe cardiovascular events include angina pectoris, cardiac dysrhythmias, or transient cerebral ischemia. Cardiovascular symptoms include tachycardia, palpitations, and syncope. CI = confidence interval.

^aAll adjusted odds ratios are adjusted for propensity score, patient age, and days from index ADHD diagnosis. In addition, the adjusted odds ratios of less severe cardiovascular events are also adjusted for cardiovascular symptoms.