TABLE 4.

Absolute risk over 9-years, number-needed-to-control, and age-adjusted parameter estimates and hazard ratios (HR) and 95% confidence intervals (95% CI) for Framingham risk factor control score for the combined outcome of any CVD (includes cardiovascular death, non-fatal myocardial infarction, angina, revascularizations, non-fatal stroke, transient ischemic attack, carotid artery surgery, and other peripheral vascular disease surgery). Score includes cholesterol control, blood pressure control, smoking, and aspirin use

	Absolute risk of any CVD events over 9 years (95% CI)	Age-adjusted HR (95% CI) (n=4182)	Model 1 HR (95% CI) (n=4164)	Number- needed-to control to prevent 1 CVD event over 9 years
0 Risk factors controlled (n= 17, 0.41%)	41.2% (21.6–64.0)	3.83(1.72–8.55)	3.54(1.59–7.91)
1 Risk factor controlled (n=594, 14.2%)	36.7% (32.9–40.7)	2.53(1.80–3.57)	2.26(1.60–3.17)	22
Non-HDL-C <130 mg/dL (n=3, 0.51%)
Blood pressure <140/<90 mmHg (n=39, 6.6%)
Aspirin use (n=28, 4.7%)
Non-smoking (n=524, 88.2%)
2 Risk factors controlled (n=1832,43.8%)	28.3% (26.3–30.4)	1.94(1.41–2.69)	1.76(1.27–2.43)	8
Non-HDL-C <130 mg/dL (n=158, 8.6%)
Blood pressure <140/<90 mmHg (n=1149, 62.7%)
Aspirin use (n=577, 31.5%)
Non-smoking (n=1780, 97.2%)
3 Risk factors controlled (n=1487, 35.6%)	25.4% (23.3–27.7)	1.80(1.30–2.50)	1.65(1.19–2.29)	6
Non-HDL-C <130 mg/dL (n=408, 27.4%)
Blood pressure <140/<90 mmHg (n=1383, 93.0%)
Aspirin use (n=1189, 80.0%)
Non-smoking (n=1481, 99.6%)
4 Risk factors controlled (n= 252, 6.0%)	20.2% (15.7–25.6)	REFERENCE	REFERENCE	5
		Test for trend P0.002	Test for trend P0.01

CVD = Cardiovascular disease

HDL-C = High-density lipoprotein cholesterol

Model 1 adjusted for age, body mass index, physical activity, and high-density lipoprotein cholesterol