Table 2.

Effects of reference drugs on the hERG K⁺ current.

Compound	Test conc. PL (μM)	hERGIC50 PL (μM)	hERG IC50 PC (μM)
		Mean ± SE
Amiodarone	0.01–0.03–0.1–0.3	0.17 ± 0.03	0.070 (Ridley et al., 2004)
Astemizole	0.001–0.003–0.01–0.03	0.012 ± 0.0008	0.006
Bepridil	0.01–0.03–0.1–0.3	0.065 ± 0.012	0.27
Captopril	1–10–100–1000	>1000	>1000
Cisapride	0.001–0.01–0.1–1	0.022 ± 0.005	0.024 (Walker et al., 1999)
Clemastine	0.001–0.01–0.1–1	0.006 ± 0.002	0.012 (Ridley et al., 2006)
Dofetilide	0.001–0.01–0.1–1	0.058 ± 0.018	0.01 (Du et al., 2011)
E-4031	0.0003–0.003–0.03–0.3	0.001 ± 0.0002	0.002
Erythromycin	1–10–100–1000	257 ± 28	236
Fluoxetine	0.1–0.3–1–3	0.39 ± 0.05	2.0
Glibenclamide	0.2–0.6–2–6	>6	>6
Haloperidol	0.001–0.01–0.1–1	0.023 ± 0.005	0.027
Ibuprofen	0.3–3–30–300	>300	>300
Moxifloxacin	0.3–3–30–300	34 ± 2	29 (Alexandrou et al., 2006)
Olanzapine	0.3–1–3–10	1.3 ± 0.2	2.1
Quinidine	0.1–0.3–1–3	0.35 ± 0.06	0.6
d,l-Sotalol	0.3–3–30–300	103 ± 20	154
Tamoxifen	0.1–0.3–1–3	0.44 ± 0.06	0.1 (Yuill et al., 2004)
Terfenadine	0.003–0.01–0.03–0.3	0.05 ± 0.01	0.015
Thioridazine	0.03–0.1–0.3–1–3	0.09 ± 0.003	0.096 (Kirsch et al., 2004)
Verapamil	0.01–0.003–0.1–0.3	0.2 ± 0.03	0.136 (Kirsch et al., 2004)